This somewhat strange word describes the programmed death of a cell caused by itself. It is a very important process and must be meticulously regulated, since if it is altered it can lead to serious pathologies such as the appearance of tumors, autoimmune or neurodegenerative diseases, defects in development or malformations.
Apostosis is essential for processes such as remodeling during embryonic development , the development of organs and systems, defense against pathogens or against the appearance of tumors, as well as to maintain cell homeostasis (establish a correct balance between division and death mobile).
There are a large number of extracellular stimuli that can lead to the death of a cell; This is the case of radiation or the lack of hormonal signals. On the other hand, the intracellular stimuli that induce apostosis processes are usually an increase in cytoplasmic calcium , incomplete mitosis, or an increase in reactive oxygen species, among others.
