NewsOmicron: This inactivated vaccine is hardly effective against the...

Omicron: This inactivated vaccine is hardly effective against the corona variant

How well did inactivated corona vaccines protect against the corona variant omicron? One of these vaccines does not perform well in a study.

Frankfurt – The Corona variant* Omikron is spreading rapidly all over the world. It has a particularly high number of mutations, especially on the spike protein. According to the Robert Koch Institute, among these amino acid changes are some that are known to affect transmissibility and immune escape. With the advent of the omicron variant, the concerns of many increased that the previously used corona vaccines * could possibly protect less well against corona infections and severe Covid 19 courses.

So far it is known: Due to the omicron variant, some vaccines, such as those from Biontech/Pfizer and Astrazeneca,* could no longer be as effective, which is why a booster vaccination is urgently recommended. According to an international study, Moderna’s vaccine is particularly suitable against the corona variant Omikron.* However, other players have now entered the vaccine market.

In addition to protein vaccines such as Novavax*, which work on the basis of viral protein particles produced in the laboratory, there are also so-called dead vaccines. One of them is Coronavac from the Chinese manufacturer Sinovac. But a study on this inactivated vaccine in particular is now delivering downright devastating results.

Dead vaccine Coronavac hardly works against Omikron: How does the Corona vaccine work?

Killed vaccines work on the basis of inactivated, i.e. killed, pathogens of the coronavirus. This is how the classic, well-known vaccines against tetanus or whooping cough work. As early as spring 2021, the WHO granted emergency approval for Coronavac, among other things. However, previous research has already shown that these dead corona vaccines have some disadvantages*.

In October 2021, a study in the journal Nature showed that the dead vaccines provided less protection against infection than the mRNA vaccines from Biontech/Pfizer and Moderna* or the vector vaccine Astrazeneca.* Other studies concluded that the amount of neutralizing antibodies is lower in inactivated vaccines.

The Omikron variant did not exist at that time, of course. This has changed now. Researchers from Hong Kong compared the effectiveness of the vaccine from Biontech/Pfizer* with the effect of Coronavac from the company Sinovac. For this purpose, it was examined how high the protection against the corona variant Omicron is when vaccinated people who received either Biontech or Coronavac as a first and second vaccination were then vaccinated with one of the two alternatives as a booster. The University of Hong Kong published the results.

Ein Mitarbeiter des Gesundheitswesens in Kolumbien zeigt eine Dosis des Corona-Impfstoffes Coronavac.


A healthcare worker in Colombia shows a dose of the Coronavac vaccine.

Corona dead vaccine against omicron variant: study delivers sobering results

It turned out that people who had been vaccinated twice with the inactivated vaccine and who also received Coronavac as a booster did not develop a sufficient number of antibodies against Omicron. It was different for those who received the vaccine from Biontech/Pfizer as a booster. Regardless of whether they had received the inactivated vaccine as the first and second vaccination, their antibodies were at a sufficient level together with the mRNA booster.

In addition, the researchers came to the conclusion that neither a double vaccination with the inactivated vaccine Coronavac nor with Biontech/Pfizer caused sufficient formation of antibodies against omicron. “All those who have already taken two doses of Comirnaty [by Biontech/Pfizer ed. Red] or Coronavac should receive a third dose of the Comirnaty vaccine six months after their second dose. In this way, they can develop optimal protection against the omicron variant,” emphasized Malik Peiris, one of the leaders of the study. (slo) * is an offer from IPPEN.MEDIA.

Rubriklistenbild: © Secretary of Health Bogota/dpa

Corona: After how many infections are you immune? Virologist provides information

Does multiple infection with the coronavirus and the associated build-up of antibodies confer immunity? Virologist Stöhr has an answer.

Change of course in corona policy: Austria reintroduces the obligation to wear masks

Shortly after the easing of many corona measures, Austria rowed back. Will the rules soon become stricter again in Germany?

Gas station murder in Idar-Oberstein: alleged perpetrator in court

A 20-year-old dies after telling a man to wear a mask. The alleged killer is now on trial.

Corona case numbers: RKI reports fewer new infections and falling incidence

The RKI announces the current number of corona cases in Germany. More than 130,000 new infections have been reported.

These corona rules now apply in Lower Saxony

Freedom Day largely does not take place in Lower Saxony. New corona rules now apply in the federal state. An overview.