Scientists from Goethe University (Germany) have been investigating the causes of thrombi caused by the AstraZeneca and Janssen COVID-19 vaccines since March and now claim that they have discovered why some coronavirus vaccines cause blood clots. blood and that, in fact, could be modified to solve this problem.
Two vaccines, one made by Oxford-AstraZeneca and the other by Johnson & Johnson, have been linked to rare bleeding disorders, particularly among women under the age of 50.
Where was the problem?
The key is in the adenovirus , the common cold virus that is used to carry the coronavirus protein to the body, that is, the adenovirus vector that both vaccines use to introduce the SARS-CoV spike protein into the body. 2, says Rolf Marschalek, leader of the study that is published in pre-print in Research Square. Once inside the cell nucleus, certain parts of the protein splice or break apart, creating mutant versions, which cannot bind to the cell membrane where major immunization takes place. Floating mutant proteins are secreted by cells in the body, causing blood clots in about one in 100,000 people , according to Professor Marschalek’s theory.
The mRNA vaccines developed by Pfizer / BioNTech and Moderna do not use this delivery system and there have been no cases of blood clotting associated with them. In their case, they deliver the genetic material to the cellular fluid (the cytosol, a fluid inside the cell where the virus normally produces proteins) and never enter the nucleus.
Blood clots are rare but concerning in the younger age group, who are at higher risk of clotting and less likely to experience serious illness from Covid. Be that as it may, the team of German scientists believe that vaccines could be modified to completely stop this adverse reaction.
The vaccine can be genetically modified so that the protein does not separate when it enters our cells . Experts say they have not yet spoken with those responsible for AstraZeneca, but that J&J has contacted their laboratory and is working to improve the injection , optimize it and that there is no possibility of causing thrombi. In this way, the researchers can explain to the companies involved how to mutate these problematic sequences, encoding the protein in a way that avoids unwanted splicing reactions, the authors clarify in their research that has not yet been peer-reviewed.
For older people who are at real risk of dying if they contract COVID-19, the benefits of protection against the virus clearly outweigh any negative side effects, regulators say. In Europe, some countries have stopped using the AztraZeneca vaccine entirely, while others, including Great Britain, recommend that younger women receive a different vaccine.
Referencia: “Vaccine-Induced Covid-19 Mimicry” Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines. Eric Kowarz, Lea Krutzke, Jenny Reis, Silvia Bracharz, Stefan Kochanek, Rolf Marschalek DOI: 10.21203/rs.3.rs-558954/v1
