LivingCOVID-19 is less severe in fully vaccinated people

COVID-19 is less severe in fully vaccinated people

The number of confirmed cases of COVID-19 worldwide is already over 270 million people with an overall mortality rate of about 2%. Cases continue to rise with the incredibly transmissible Ómicron variant and its sub-variant called ‘silent Ómicron’.

COVID-19 vaccines are effective tools to control the pandemic; however, they are not 100% effective in preventing disease . Now, according to a new multicenter study published in the journal Radiology, the clinical and imaging features of emerging COVID-19 infections, such as the detection of ribonucleic acid (RNA) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV) antigen. -2) , tend to be milder in fully vaccinated patients than in partially vaccinated or unvaccinated patients.

“Although the risk of infection is much lower among vaccinated people, and vaccination reduces the severity of the disease, the clinical and imaging data of emerging COVID-19 infections have not been exposed in detail,” comments Yeon Joo Jeong. , from the Department of Radiology and Biomedical Research Institute of Pusan National University Hospital in Busan, South Korea and leader of the work. “The purpose of this study was to document the clinical and imaging characteristics of emerging COVID-19 infections and compare them with those of infections in unvaccinated patients.”

The study involved 761 people hospitalized with COVID-19 from an open data registry for COVID-19 between June and August 2021 . Baseline chest radiographs were divided into three groups, based on their vaccination status. The researchers evaluated differences between clinical and imaging features and analyzed associations between clinical factors, including vaccination status, and clinical outcomes.



The conclusions from respiratory samples collected 14 days or more after receiving all recommended doses of COVID-19 vaccines or not were very clear. The researchers found that 47 of the patients were fully vaccinated (6%), while 127 were partially vaccinated (17%) and 587 were unvaccinated (77%).

Fully vaccinated people who contracted COVID-19 were less likely to develop severe illness than those who were not vaccinated. Thus, being fully vaccinated was associated with a lower risk of requiring supplemental oxygen than the unvaccinated, as well as a lower risk of admission to the intensive care unit (ICU).

“Despite these differences, mechanical ventilation and death in hospital occurred only in the unvaccinated group,” Jeong said. “In addition, after adjusting for baseline clinical characteristics, the analysis showed that fully vaccinated patients had a significantly lower risk of requiring supplemental oxygen and ICU admission than unvaccinated patients.”

And this happened even with older people. Fully vaccinated seniors were more likely to get a serious infection, but their risk was still lower than that of unvaccinated or partially vaccinated people.

More studies will be needed as new variants of the coronavirus emerge, but this research sheds light on the clinical effectiveness of vaccination against COVID-19.

Referencia: Jong Eun Lee, Minhee Hwang, Yun-Hyeon Kim, Myungjin Chung, Byeonghak Sim, Kum Ju Chae, Jin Young Yoo, Yeon Joo Jeong. Imaging and Clinical Features of COVID-19 Breakthrough Infections: A Multicenter Study. Radiology, 2022; DOI: 10.1148/radiol.213072 / Mark L. Schiebler, David A. Bluemke. Seeing Is Believing: COVID-19 Vaccination Leads to Less Pneumonia at Chest CT. Radiology, 2022; DOI: 10.1148/radiol.220129

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